HELIXERA
Next-Generation Cellular Revitalizer
PDRN/PN with G (Glutathione Power)
•Optimized by Science: 0.2% FDN/68 kDa Perfection
Helixera combines the world's most advanced polynucleotide and polydeoxyribonucleotide technology with glutathione enhancement, delivering unmatched skin rejuvenation and regeneration. Our precisely engineered formulation sets a new gold standard for purity, consistency, and advanced skin care innovation.
The Helixera Advantage
A New Standard in Skin Regeneration
Foundation of Cellular Regeneration
PDRN & PN serve as essential building blocks for cellular repair and regeneration, activating adenosine A2 receptors and the salvage pathway for complete tissue renewal.
Scientifically Optimized Rejuvenation
Precisely engineered with 0.2% FDN at 68 kDa molecular weight, ensuring optimal penetration and maximum therapeutic efficacy for visible results.
Clinical Validation & Excellence
Meeting the highest standards with >90% DNA content, <0.5 EU/mg endotoxin, and pH balanced at 6.5-7.5 for optimal safety and efficacy.
Salmon DNA Technology
PDRN and PN silver salmon derived substances
97% Human-Salmon Genetic Similarity
DNA extracted from salmon is highly biocompatible with the human body and can be safely administered without discomfort.
PDRN
POLYDEOXYRIBONUCLEOTIDE
Pharmaceutical Materials
- Tissue Regeneration
- Corneal Regeneration
- Musculoskeletal Regeneration
PN
POLYNUCLEOTIDE
Medical Device & Skin Regeneration
- Skin Regeneration
- Articular Cartilage Regeneration
- Osteogenesis Promotion
POLYMERIZED
DNA
Cosmetic & Food Materials
- Anti-wrinkle & Skin Regeneration
- Anti-aging Functional Food Materials
Total Process Control
Visible Regeneration Results
The Science Behind Helixera
Foundation of Cellular Regeneration: PDRN & PN Technology
Understanding PN vs PDRN
Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN) are DNA fragments that act as essential building blocks for cellular repair and regeneration. When introduced into the skin, they stimulate fibroblast activity, enhance collagen production, and activate the body's natural healing mechanisms.
PN (Polynucleotide)
High molecular DNA fragments extracted from the testis of salmon/trout
Biocompatible material with high human compatibility and low risk of foreign body effects and side effects
Ingredients approved as a class 4 medical device by the Ministry of Food and Drug Safety (KFDA)
#Skin moisturizing #Regeneration of damaged skin #Improvement of elasticity and fine wrinkles
PDRN (Polydeoxyribonucleotide)
DNA material extracted from the testis of salmon/trout
Compared to PN, it has a small molecule and a single structure, so it helps relieve inflammation with wound healing and anti-inflammatory effects
Used as a raw material for medicines or cosmetics
#Strengthening skin barrier #Wound treatment and tissue repair #Acne scars, pore improvement #Skin cell regeneration effect
| Division | PN (Polynucleotide) | PDRN (Polydeoxyribonucleotide) |
|---|---|---|
| DNA Source | Salmon Trout's Testis/Sperm | Salmon Trout's Testis/Sperm |
| Compounds | Long-Polymeric molecules | Short-Polymeric molecules |
| Permissions | Medical device raw materials | Cosmetics, pharmaceutical raw materials |
| Use | Wrinkle improvement, skin elasticity | Wound healing, tissue repair, arthritis treatment |
| Average Molecular Weight | >1500 kDa | 50 - 1500 kDa |
| Functions | Skin support role | Anti-inflammatory Cell Viability, ECM Angiogenesis Wound healing and tissue repair |
| Application | 3D matrix | Tissue injury → Recovery |
Note: PN has a larger molecular weight than PDRN, so it has higher viscosity and lasts longer. PDRN is usually used as a raw material for pharmaceuticals and cosmetics, and PN is used as a raw material for medical devices.
PDRN Mode of Action: Activation of Adenosine A2 Receptors
Anti-inflammatory Effect
Suppresses TNF-α, IL-6 while increasing IL-10 for reduced inflammation
Tissue Regeneration
Promotes secretion of EGF, FGF, VEGF, and IGF growth factors
Angiogenesis
Stimulates VEGF production for new blood vessel formation
Pharmaceutical Grade Specifications
Product Specification for Medical Device
Product: Sodium Polynucleotide (PN) for medical device
| Item | Specification | Inspection Method |
|---|---|---|
| Appearance | White | Visual Inspection |
| Loss on Drying | <10.0% | Ambient pressure drying method |
| Identification | 1.5 to 2.0 | Absorption ratio at 260nm/280nm |
| Heavy metal(as Pb) | <10ppm | General test, Heavy metals test method |
| DNA Content | >90% | Absorption spectrophotometry |
| pH(1.0% aqueous solution) | 6.5~7.5 | pH determination |
| Average molecular weight (Mw) | >1,500KDa | Tape station system |
| Total bacteria | <100 cfu/g | Standard Agar Medium 48hr culture |
| Endotoxin | <0.5 EU/mg | Gelation method |
| Protein analysis | <1% | Biuret method |
High molecular weight >1500 kDa for 3D matrix formation and wrinkle improvement
Product Specification for Cosmetic
Product: Sodium Polydeoxyribonucleotide (PDRN) for Cosmetic
| Item | Specification | Inspection Method |
|---|---|---|
| Appearance | White | Visual Inspection |
| Loss on Drying | <10.0% | Ambient pressure drying method |
| Identification | 1.5 to 2.0 | Absorption ratio at 260nm/280nm |
| Heavy metal(as Pb) | <10ppm | General test, Heavy metals test method |
| DNA Content | >90% | Absorption spectrophotometry |
| pH(1.0% aqueous solution) | 6.5~7.5 | pH determination |
| Average molecular weight (Mw) | <300KDa | Tape station system |
| Total bacteria | <100 cfu/g | Standard Agar Medium 48hr culture |
| Endotoxin | <0.5 EU/mg | Gelation method |
| Protein analysis | <1% | Biuret method |
Optimized molecular weight <300 kDa for tissue injury recovery and wound healing
Helixera Product Line
Next-Generation Cellular Revitalizer with PDRN/PN + Glutathione Power
Scientifically optimized rejuvenation formula
Sodium Polynucleotide
Medical device raw material with long-polymeric molecules for 3D matrix formation and superior skin support role.
- Molecular weight >1500 kDa
- Wrinkle improvement & skin elasticity
- KFDA Class 4 medical device
Sodium Polydeoxyribonucleotide
Cosmetic and pharmaceutical raw material with short-polymeric molecules for tissue repair and wound healing.
- Molecular weight 50-1500 kDa
- Anti-inflammatory & angiogenesis
- Cell viability & ECM enhancement
Glutathione Power
Enhanced formula with glutathione infusion for superior antioxidant protection and skin brightening effects.
- Optimized 0.2% FDN concentration
- 68 kDa molecular perfection
- Radiant & youthful skin
Pharmaceutical Excellence
DNA Purity
>90% DNA content
Absorption spectrophotometry verified
Endotoxin Free
<0.5 EU/mg
Gelation method tested
pH Balanced
6.5-7.5 pH
Optimal skin compatibility
Sterility
<100 cfu/g bacteria
48hr agar culture verified
Clinical Applications
Versatile solutions for various skin concerns and treatment protocols
Anti-Aging Therapy
Comprehensive anti-aging treatment targeting fine lines, wrinkles, and loss of skin elasticity. Restores youthful appearance through cellular regeneration.
Skin Brightening
Advanced brightening protocol for hyperpigmentation, dark spots, and uneven skin tone. Promotes radiant, luminous complexion.
Scar Reduction
Targeted treatment for acne scars, surgical scars, and stretch marks. Promotes tissue remodeling and improved skin texture.
Post-Procedure Recovery
Accelerates healing after aesthetic procedures including laser treatments, chemical peels, and microneedling. Reduces downtime significantly.
Hair Restoration
Innovative scalp treatment for hair thinning and loss. Stimulates follicle regeneration and promotes healthy hair growth.
Preventive Care
Proactive skin maintenance program for preventing premature aging and maintaining optimal skin health at any age.
Experience the Helixera Revolution
Join leading dermatologists and aesthetic professionals worldwide who trust Helixera for superior skin regeneration